o-Methoxy Cinnamaldehyde


O-methoxy cinnamaldehyde is found in Cinnamon bark oil and Cassia oil. The chemical formula for o-methoxy cinnamaldehyde is C10H10O2. It is also known by the other names such as 2-methoxy cinnamaldehyde, o-methoxy cinnamic aldehyde, Trans-2- Methoxycinnamaldehyde and so on.


Attributes of o-Methoxy cinnamaldehyde:

It appears as light yellow crystals with a distinct spicy aroma.

Therapeutic properties of o-Methoxy Cinnamaldehyde:

The major therapeutic properties of o-Methoxy Cinnamaldehyde are as follows:

Antibiotic effect:

According to the study “Isolation, purification, and antibiotic activity of o-Methoxy Cinnamaldehyde from Cinnamon”, O-Methoxy Cinnamaldehyde obtained from powdered cinnamon completely inhibits the growth and production of toxin of mycotoxin producing fungi.

It suppresses the growth of fungi, namely Aspergillus flavus, Aspergillus parasiticus, Aspergillus versicolor, Aspergillus ochraceus and five dermatophytoses species, for example, Microsporum cannis. O-methoxy cinnamaldehyde exhibit antifungal activity.

Anti-inflammatoryand antioxidant activity:

o- Methoxy cinnamaldehyde possess anti-inflammatory property.

A study titledAnti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts – identification of E-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds” was carried out to investigate the anti-inflammatory activity of the essential oil of Cinnamomum zeylanicum and Cinnamomum cassia and their constituents namely E-cinnamaldehyde and o- Methoxy Cinnamaldehyde.

It was determined that E-cinnamaldehyde and o- Methoxy cinnamaldehyde potentially exhibit anti-inflammatory activity.

A study titled “2-methoxycinnamaldehyde from Cinnamomum Cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction” was conducted to investigate the effects of o-methoxycinnamaldehyde against myocardial ischemia and reperfusion injury in rats.

It was concluded that o-Methoxy cinnamaldehyde because of its anti-inflammatory and antioxidant property offers protection of myocardial injury in rats by Ho-1 induction.

Anticancer activity:

In the study “Cinnamomum verum component 2-methoxycinnamaldehyde: a novel antiproliferative drug inducing cell death through targeting both topoisomerase I and II in human colorectal adenocarcinoma COLO 205 cells”, the anti-proliferative effect and anticancer activity of o-methoxycinnamaldehyde was studied.

In this study, it was determined that o-methoxy cinnamaldehyde exhibited antiproliferative activity in vitro by cytotoxicity and inhibitions of the activities topoisomerase I and II, which are cellular growth markers and upregulating the pro-apoptotic molecules that are associated with increased lysosomal vacuolation.

Further, it exhibits anticancer activity by reducing the tumor burden in cancerous cells in lungs, liver, skin and in T-lymphoblastic leukemia.

Reference Links:



  1. o-Methoxy cinnamaldehyde by PubChem
  2. Isolation, purification, and antibiotic activity of o-methoxycinnamaldehyde from cinnamon
  3. Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts – identification of E-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds.
  4. 2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction.
  5. Cinnamomum verum component 2-methoxycinnamaldehyde: a novel antiproliferative drug inducing cell death through targeting both topoisomerase I and II in human colorectal adenocarcinoma COLO 205 cells.