gamma-Eudesmol


Gamma-eudesmol is a sesquiterpene present mainly in the wood oil of the plant species Callitris collumellaris, Callitris intratropica, Callitris glaucophyla, which are found in Australia.

It is also present in the essential oil of Juniperus virginiana, Cajuput oil, Eucalyptus oil, Guava fruit oil etc.,

The molecular formula for gamma-eudesmol is C15H26O. It is also known by various other names such as (+)-gamma-eudesmol, Uncineol, Machilol, Selinenol and so on.

Attributes of Gamma-eudesmol:

Gamma-eudesmol owns a medium waxy smell.

Therapeutic attributes of gamma-eudesmol:

The primary curative properties of gamma-eudesmol are as follows:

Cytotoxicity:

The study titled ‘Eudesmol isomers induce caspase-mediated apoptosis in human hepatocellular carcinoma HepG2 cells’ was conducted to investigate the cytotoxic effect of eudesmol isomers, namely alpha-eudesmol, beta-eudesmol and gamma-eudesmol against cancerous cells in liver.

It was found that the three eudesmol isomers exhibited potential cytotoxic activity against cancerous cells in liver by reducing the proliferation and causing the death of tumor cells by caspase-mediated apoptosis.

According to the study ‘In vitro and in vivo antitumor effects of the essential oil from the leaves of Guatteria friesiana’,  it was found that the antitumor effects exhibited by the essential oil from the leaves of Guatteria friesiana is contributed by the eudesmol isomers, alpha-eudesmol, beta-eudesmol and gamma-eudesmol. Further, they also show signs of significant cytotoxic activity against tumor cells.

Reference Links:

  1. Gamma-eudesmol by PubChem
  2. Eudesmol isomers induce caspase-mediated apoptosis in human hepatocellular carcinoma HepG2 cells
  3. In vitro and in vivo antitumor effects of the essential oil from the leaves of Guatteria friesiana