Menthyl acetate

Menthyl acetate is one of the major constituents of mentha piperita, a natural monoterpene which imparts the minty flavor and fragrance to peppermint. The acetate is an acetate ester of menthol and has an earthy, weedy, berry like odor and taste to it. On dilution, the fresh smell is similar to that of mint and rose.

It is colorless to pale yellow in color, and is frequently used in shampoo, anti-perspirants/deo, tablet soap, pot pourri, bath/shower gel, incense, liquid detergent, creams and lotions, fabric softener, and talcum powder. It is preferred when compared to menthol as it has a mild minty smell and flavor.

Menthyl acetate also goes by other names such as, 2-Isopropyl-5-methylcyclohexyl acetate, 5-methyl-2-(1-methylethyl)-, cis-1,3,trans-1,4-; Menthol, acetate, (1α,2β,5α)-; (+/-)-Menthol acetate; Cyclohexanol, acetate, (1α,2β,5α)-;  5-methyl-2-(1-methylethyl)-, and Cyclohexanol,

Menthyl acetate doesn’t stand alone and is mostly noticed for its effectiveness in essential oils of minty plants. A research conducted examined ‘the of biosolid levels on yield and chemical composition of Mentha piperita L. essential oil.’

The results proved that menthyl acetate was successfully derived from Mentha piperita in many treatments in the highest form. Menthyl acetate was found in the concentration of 3–10%, helping the oil contribute to the therapeutic qualities that were attributed to menthyl acetate.

Menthyl acetate is found in essential oils like Peppermint and is said to contribute to therapeutic properties such as anesthetic, antiseptic, antiseptic, antiphlogistic, antispasmodic, cordial, sudorific, stimulant and nervine properties.

Reference Links:

  1. Menthyl acetate by Wikipedia
  2. Yield and composition of the essential oil of Mentha piperita L. (Lamiaceae) grown with biosolid published in the Brazilian Journal of Plant Physiology

Geranial

Geranial is an oily liquid aldehyde, also known as citral A and is an E-isomer of Citral. Citral is a pair or a combination of terpenoid which goes by the name lemonal or 3, 7-dimethyl-2, 6-octadienal.

Geranial cannot be characterized alone, and it goes hand in hand with the nature and qualities of citral. It has a rich lemon aroma.

Citral is widely available in natural form and can be extracted from several plant oils such as lemon(2-5%), Calypranthes parriculata (about 62%), Litsea lemon verbena (30-35%), lemon ironbark (26%), lemongrass (65-85%), cubeba (70-85%), Lindera citriodora (about 65%), lemon balm (11%), lime (6-9%),  petitgrain (36%), Ocimum gratissimum (66.5%), lemon myrtle (90-98%), Litsea citrata (90%), lemon tea-tree (70-80%), and orange.

As you can see that its derived from most plant that belong to the lemon family, and this makes it quite obvious where Geranial expresses its prominent lemon fragrance.

Due to this citrus effect, it is used in perfumery. Therapeutically geranial has a strong fragrance and is highly capable in keeping away insects, and also exhibits sedative and antimicrobial qualities.

Uses of Geranial:

Geranial in citral is seen to have a sensitivity effect on use, and as per the International Fragrance association, it has been advised that citral be used with desensitizing agents.

On the grounds of therapeutic usage, citral is seen to be effective in regards to genotoxicity and as a carcinogenic, though test claim that they have dose dependent effect on the kidneys. Geranial can also be used to treat infections in relation to the urinary tract and also in the treatment of kidney stone.

Effect of Geranial in Chemotherapy:

A study was conducted to understand the effect of ginger on chemotherapy induced nausea and vomiting in cancer patients. The chemical constituents of ginger include neral, borneol, b-fellandren, sogaoles, gingeroles, geranial, sineol, bisabolen, oleoresin, zingiberen, diterpenes, lypids, protein, starch and vitamins.

During the study the participants were divided into 2 groups, one received the anti-emetic, and the other was given ginger. The results proved that the group receiving the anti-emetic was only 75% effective when compared to the group receiving only ginger which proved to have completely absence of nausea and vomiting.

Effect of Geranial attributes in Lemon Grass:

To understand the therapeutic qualities of lemon grass a study was carried out. The result proved that lemon grass with the constituents of lemon grass, Citral α, Nerol Geraniol, Citral β, Terpinolene, Citronellal, Myrecene, Geranyl acetate, and Terpinol Methylheptenone showed several therapeutic activities.

Lemon grass had proved hypoglycemic, antimutagenicity, antimalarial, antimycobacterial, antioxidants, neurobehaviorial, anti-amoebic, antidiarrheal, antifungal, antibacterial, and anti-inflammatory properties.

Prophylactic & Antinociceptive effects of Geranial:

A study was carried out to understand the effects of citral when administered orally to treat conditions of inflammation, acute and chronic nociception, and gastric ulcers caused by the usage of NSAIDS.

The result suggested that citral repressed the pain responses caused by inflammation and the neurogenic effects caused as an effect of intra-plantar injection of formalin; it also displayed therapeutic anti-nociceptive and prophylactic effects towards mechanical hyperalgesia seen in plantar incision surgery.

Citral was also seen displaying gastro-protective effects towards ulcers caused by NSAIDs. All these effects prove the positive response of citral towards the treatment of pain.

Reference Links:

  1. Citral by Wikipedia
  2. Scientific basis for the therapeutic use of Cymbopogon citratus, stapf (Lemon grass), published in the Journal of Advanced Pharmaceutical Technology and Research
  3. Citral: A monoterpene with prophylactic and therapeutic antinociceptive effects in experimental models of acute and chronic pain, published in European Journal of Pharmacology

Carvone

Carvone is a monoterpene hydrocarbon seen in excessive quantities in the seeds of caraway, dill and spearmint. The chemical belongs to the family of terpenoid. It is a liquid and is seen in a color that is slightly yellow to colorless, and is soluble in ether, alcohol, propylene glycol, chloroform, and mineral oils.

Carvone is seen as two mirror images, R-(–)-carvone and S-(+)-carvone. They two have very different distinctive smells that can be identified even by squirrel monkeys.

R-(–)-carvone smells like spearmint leaves and S-(+)-carvone smells like that of caraway seeds. It has been in use from ancient times, and has been used for its medicinal purpose in Rome.

It was only in 1877 when a pure form of carvone was isolated by Franz Varrentrapp. When it was first discovered, Schweizer called it carvol. Carvone is isolated in large quantities from caraway seeds (60-70%), in dill seed oil (40-60%), in spear mint oil (50-80%) and is also found in mandarin orange peel oil.

R-(–)-carvone is extracted from spearmint leaves, and is recognized to be a valuable source that helps with Carvone extracts naturally. R-(–)-carvone, which hits upon its use in commercial purposes finds it’s availability in limonene, kuromoji oil, gingergrass oil and peppermint oil.

Studies conducted state that carvone possesses decongestant, diuretic, antiviral, and tonic biological properties. They also seem to a have an elevated anti-tumor effect as seen in one of the studies conducted at the US National Cancer Institute on mice.

Uses of Carvone:

In general carvones are used in the food industry, and in aromatherapy like many essential oils, it is also used in air fresheners for it pleasant smell. It also has several therapeutic effects that make it a perfect choice in the treatment of certain medical conditions.

Carvone in Food:

It has been used in food for over millennia. The very famous Wrigley’s Spearmint Gum uses natural spearmint oil that has been extracted from Mentha spicata, and the other spearmint flavored Life Savers use the same.

Carvone that has been extracted from dill and caraway have also been in use in the food industry. The famous European drink Kummel is created with a mixture of an extract from caraway and alcohol.

Carvone in Agriculture:

It is commonly used in Netherlands to prevent the sprouting of potatoes that have been kept in storage.

A study was conducted to understand the antifungal activity of carvone on potato tubers and other plant diseases, it was also meant to analyze the suppression of sprout in potatoes.

The results suggested that during in-vitro experiments, carvone exhibited antifungal activity towards various fungal species. Thus carvone has taken the trade name ‘talent’ to serve as an antifungal agent in the treatment of potato tubers in Netherlands.

Carvone as a Pesticide:

The extract of carvone is seen to be effective as a mosquito repellent, and at present it is being reviewed by the U.S. Environmental Protection Agency to check its potency and safety as a pesticide.

Carvone & its Therapeutic Uses:

Carvone displays biological activities as an expectorant tonic, disinfectant, cardiac, stomachic, astringent, carminative, diuretic, and digestive stimulant.

Carvone as a Relaxant:

Carvone is a major constituent of the oil extracted from the caraway seed and is seen in huge quantities with a percentage as far as 99%. As a relaxant it helps relieve from stress, emotional exhaustion, and clear respiratory tracts by acting as an expectorant in the treatment of coughs, bronchitis, and bronchial asthma.

In the treatment of laryngitis and sore throats it helps by flushing out the toxins to aid in a speedy recovery. It aids in relaxing the digestive system and in the treatment of stomach colic, gastric spasms, flatulence, and nervous digestion. It’s also used in clearing the urinary tract as well.

Reference Links:

  1. Carvone by Wikipedia
  2. The use of carvone in agriculture: sprout suppression of potatoes and antifungal activity against potato tuber and other plant diseases, published in Industrial Crops and Products Journal