Limonene

Limonene is a neutral liquid hydrocarbon classified as a cyclic terpene. Limonene is the name that has been derived from the word lemon as it’s one of the major constituents seen in the rind of citrus fruits.

It is the Limonene in the rind that contributes to their odor. The more common d-isomer possesses a strong smell of oranges. The chief element of most citrus odor is (+)-limonene which can be up to 97% of the oil. It is in charge for the base sensory character of the citrus oils.

Limonene is a chiral molecule, and biological sources produce one enantiomer: the most important developed source, citrus fruit, contains D-limonene ((+)-limonene), which is the (R)-enantiomer. Racemic limonene is known as dipentene.

D-Limonene is retrieved for commercial purposes from citrus fruits through two primary procedures: steam distillation and centrifugal separation.  It is commonly used as base in producing cleaning product as a solvent; and is also used in chemical synthesis as a precursor to carvone.

Essential Oils with Limonene:

The few essential oils that contain Limonene are, Wild Orange (90% D-Limonene), Bergamot (30% D-Limonene), Lemon (70% D-Limonene), Grapefruit (92% D-Limonene) and Lime (65% D-Limonene)

Medicinal uses of Limonene:

The most important therapeutic uses of Limonene are:

Metabolism and Weight loss:

Appetite Control:

Limonene acts as a mild appetite suppressant, which can be used by individuals who are looking to curtail their appetite in case of diet plans or in nutritional requirements.

According to a study in 2002, limonene was seen to exhibit characteristics of  probiotics such as adjuvants , digestive enzyme inhibitors such as hibiscus tea,  marine algae, L-arabinose, Nomame Herba, inhibit glucose intake like phlorizin, and anorexics like monoterpenes such as perillyl alcohol, d-limonene.

This makes things a lot safer and easier for individuals looking to execute appetite control, as they can opt for the more natural, healthy option rather than to go in for lethal procedures.

Fatty Liver:

Limonene helps combat a fatty liver.  Limonene was included in the diet of animals that were regularly fed a high fat diet. The D-Limonene helped prevent the fat buildup resulting in a non- fatty liver seen in animals. It even showed signs of preventing insulin resistance.

According to a study in 2012, regular supplementation of D-limonene caused a reverse action on HFD and L-NAME-induced changes, and retuned pathologically damaged liver and pancreas to normal.  The study showed that it eased out insulin resistance and the effects of oxidative stress-induced liver injury in conditions of a fatty diet.

Anti- Inflammatory:

Limonene is a naturally found nutrient that helps manage inflammation. Limonene has potent antioxidant and anti-inflammatory properties and can be used on a daily basis as a routine health program. A study in 2010 suggests that “D-limonene may be considered a potential anti-inflammatory candidate.”

Antifungal & Antibacterial Properties:

Citrus oils are composed of monoterpenes, in particular D-limonene, which exhibit antibacterial and antifungal characteristics, and even inhibit the growth of certain parasites as well.

The 2016 study concluded that, “The mixture of oils containing limonene like most citrus oils, along with MgCl could be used as a natural antibacterial and anti-inflammatory agent”

Cytotoxic Properties:

Limonene is good for the body in general and should be a part of daily diet, exercise and a healthy lifestyle program toward the goal of reducing breast cancer risk.  The mechanism of benefit is not limited to breast cancer; researchers have proved that Limonene has anti-cancer properties for liver cancer, pancreatic cancer, gastric cancer, lung cancer, and prostate cancer.

D-Limonene Chemoprevention of Breast Cancer, a study conducted in the year 1994 suggested, “Usage of limonene was seen to decrease the development of mammary carcinoma, and also increased the dormancy period or carcinogenic cells. However the usage of Limonene did make much of a difference in the percentage of carcinomas with activated rats.”

Non- Medicinal uses of Limonene:

It is used as a botanical insecticide, the element d enantiomer is most active as an insecticide.

D-limonene is an alternative medicine that is marketed to relieve gastro esophageal problems and heartburn.

It is used as a fragrant alternative to turpentine, and also as a paint stripper.

Philatelists use air propellants, containing limonene to remove self-adhesive postage stamps from envelope paper.

It is also seen in all-natural commercial air fresheners.

Its ability to dissolve oils and its lemony fragrance makes it an important ingredient in cleaning products such as hand cleansers.

Limonene is obtained from a renewable source such as citrus oil and as a byproduct of orange juice manufacturing. It is extremely strong and hence it’s increasingly being used as a cleaning solvent to remove oil from machine parts, and in household cleaning as well.

Limonene is also frequently seen in cosmetic products such as aftershave lotions, masks, bath products, perfumery, and many other products as a flavoring agent.

Reference Links:

  1. Limonene by Aromatic Plant Project
  2. Limonene by Wikipedia
  3. Dietary d-limonene alleviates insulin resistance and oxidative stress-induced liver injury in high-fat diet and L-NAME-treated rats, published in the European Journal of Nutrition and PubMed

Camphene

Camphene is a monoterpene that is bicyclic and exhibits a pungent aroma. It is soluble in general organic solvents and vaporizes at room temperature.  It is seen as a vital constituent in Citronella oil, Ginger oil, Camphor oil, Cypress oil, Neroli and Valerian. In the industry, this oil is produced by catalytic isomerization of alpha-pinene.

Commercially, Camphene is seen used as a food additive and in the production of fragrances. Camphene is similar to that of camphor and is a white crystalline solid which imparts a fragrance that is close to camphor. When heated, these crystals give out vapors that cause irritation to the eyes and throat. It is commonly used in the production of insecticides and man-made camphor.

Therapeutic Properties of Camphene:

The predominant remedial attributes of Camphene are as follows:

Antifungal properties of Camphene:

Camphor and camphene in the essential oil of Sage attributes to its antifungal properties. It works effectively in the treatment of fungal skin infections, dysentery, athlete’s foot and dermatitis. It is for the antifungal property displayed by camphene and camphor in Sage oil that it finds its use in skin care products.

Anti-biotic and Cytotoxic properties of Camphene:

The constituents like Camphene, Cineole and Eugenol seen in Tulsi oil is responsible for treating bacterial, fungal and viral infections that affect the respiratory system. It completely cures congestion, and has also been used in the treatment of severe respiratory disorders like bronchitis as well.  It has also been reported that the active ingredients present in Tulsi oils can be used to treat damage caused to the lung by smoking cancer and tuberculosis.

Camphene found in Holy Basil leaves and in Tulsi leaves can be used directly as a paste or as an oil extract on the skin to treat antifungal and antibacterial diseases. The extract can be used to keep away mosquitoes, and to create a cooling effect on the irritated parts of the skin.

Antioxidant properties of Camphene:

Camphene along with vitamin C acts as an antioxidant and helps repair damage caused by stress. They work together and exhibit a soothing effect on the nerves, thereby reducing blood pressure, inflammation, and eventually stress.

Analgesic properties of Camphene:

Constituents of Tulsi such as Eugenol, Camphene, Methyl-Chavicol, Carvacrol, and Cineol, have been understood to show sedative, anti-congestive, analgesic, and disinfectant properties. Tulsi and its essential oil can be used to treat sinus pressure, migraines, cough and cold, and even high blood pressure.

 Hyper-Lipidemia and Camphene:

Camphene was used in a study to treat the effects of hyperlipidemia and its reduction. The results proved that camphene was quite effective in treating hyperlipidemia and can be used in conditions associated with cardiovascular disease.

Antinociceptive properties of Camphene:

To study the antinociceptive and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate an experiment was carried out. It was identified that the entire three constituents displayed anti-inflammation and analgesic properties, with p-cymene and geranyl acetate showing minimal therapeutic uses. It was decided that camphene had better opportunities in the pharmacological angle enabling it to find a place in the development of new therapeutic ideologies.

Reference Links:

  1. Camphene, a Plant-Derived Monoterpene, Reduces Plasma Cholesterol and Triglycerides in Hyperlipidemic Rats Independently of HMG-CoA Reductase Activity, published in PLOS journals
  2. Antinociceptive Activity and Redox Profile of the Monoterpenes (+)-Camphene, p-Cymene, and Geranyl Acetate in Experimental Models, published in Hindawi, International Scholarly Research.
  3. Comparative antifungal activities and biochemical effects of monoterpenes on plant pathogenic fungi by Damanhour University and Alexandria University, Egypt

1,8-Cineole

Eucalyptol is a cyclic ether and a monoterpenoid. It is identified and ascribed the name eucalyptol in 1870 by F. S. Cloez. It is a natural organic compound that is a colorless liquid, also known by various names like 1,8-cineol, cajeputol, 1,3,3-trimethyl-2-oxabicyclo[2,2,2]octane, 1,8-oxido-p-menthane,  1,8-epoxy-p-menthane,  eucalyptole , eucalyptol, and cineole.

The name eucalyptol was given to it based on the dominant portion of Eucalyptus globulus oil. The constituent Eucalyptol is seen in 90 percent of the essential oil in most species of Eucalyptus oil. It’s component is majorly constituted of 1,8 cineole syn eucalyptol and monoterpenes, and hence it gets its’ name Eucalyptol.

1,8-Cineole  is also found in Common Sage,  Bay leaves, Camphor laurel, Tea tree, Sweet basil, Wormwood, Mugwort, Rosemary, Cannabis sativa and other aromatic flora.

Therapeutic Properties of 1,8-Cineole:

1,8-Cineole finds itself serving multiple therapeutic purposes such as  analgesic, anti-inflammatory, antibacterial, airborne antimicrobial, antioxidant, antiviral, mucolytic, hypotensive, antispasmodic and it also increases the cerebral blood flow.

1,8-Cineole & Its Uses:

Flavoring and Fragrance:

A report in 1994 stated that the top cigarette companies used eucalyptol as an ingredient in about 599 additives in cigarettes, to improve the flavor. Cineole-based eucalyptus oil is used as a flavoring in various products, including beverages, confectionery, baked goods, and meat products, owing to its pleasant spicy aroma and taste. 1,8-Cineole is also used in flavorings, fragrances, and cosmetics.1 8-cineole

Remedial benefits of 1,8-Cineole:

In the areas of medicine, 1,8-Cineole is widely used as an ingredient in many popular brands of cough suppressant, mouthwashes, and as well as an inactive ingredient in body powder. It serves well in treating system related disorders as mentioned below.

Digestive system: 

A study conducted in 2010 with details from the Aromatherapy Journal of the NAHA states that Eucalyptol does play a crucial role against Candida and fungi. It is seen to restrict the filamentation in fungi, and is also effective on intestinal parasites that cause diarrhea.

It’s does exhibit anti-fungal activity on candida albicans.  When the leaves of Eucalyptus globulus were taken internally during an experiment with diabetic rats, Candia albicans and its proliferation were inhibited.

Musculoskeletal system: 

It can be used in the treatment of arthritis, rheumatism, muscular aches and pains, sprains and plantar fasciitis. Studies suggest that both analgesic and anti-inflammatory activity, were projected by Eucalyptus globules and Eucalyptus citriodora.

Immune System:

The Aromatherapy Journal (2010) of the NAHA indicates, “Eucalyptus globules was able to instinctively put into action a cell-meditated immune response, making it actively function as a immuno-regulatory agents which can be used in infectious diseases, and in chemotherapy, as adjuvant in immuno-suppressive pathologies.”

Respiratory system: 

1,8-Cineole is indicated in several respiratory conditions right from sinusitis, asthma, acute bronchitis and chronic bronchitis. It is also preferred in the treatment of sore throat and infections such as laryngitis, for its antiseptic qualities.

It is also used to clear the head especially when used in a combination of Peppermint and Rosemary under conditions of nasal congestion, coughs, cold, flu and pertussis.

1, 8-cineole is seen to provide positive responses even under the conditions of severe respiratory illnesses such as lung function parameters during the treatment of COPD and the common cold.

Eucalyptus globules have been identified to create positive battling effects on bacterial strains which have been isolated from respiratory infections. It has been proved effective for its growth restraining activity against bacterial strains including Haemophilus influenzae, Streptococcus pyogenes, H. parainfluenzae, S. pneumoniae, Stenotrophomonas maltophilia and Staphylococcus aureus.

Skin: 

For the skin, 1,8-Cineole is used in the treatment of shingles, herpes simplex, measles, acne, chickenpox, ulcers, wounds, boils, burns, cuts. The National Association for Holistic Aromatherapy Journal concurs, “bacteriostatic and bactericidal activity was extensively displayed by 1,8 cineole”.

Insecticide and repellent

Eucalyptol is used as an insect repellent and as an insecticide. This oil is said to elevate territorial behavior and specifically attracts the male bees. This was done so these males would periodically leave their territories to forage for chemicals such as cineole, to attract and mate with females, to synthesize pheromones.

Reference Links:

  1. 1,8-Cineole by Wikipedia
  2. About Eucalyptus globulus and 1,8 cineole by The School for Aromatic Studies
  3. Eucalyptus globulus & 1, 8 cineole – Seasonal Self Care Issue by The National Association for Holistic Aromatherapy Journal