Myristicin

Myristicin is an organic compound present in the essential oil of Nutmeg, Mace, Parsley, Black pepper, Carrots and Dill. It constitutes about 4-8% of the essential oil of Nutmeg.

The chemical formula for Myristicin is C11H12O3. It is also known by other names such as methoxysafrole and Myristicine.

Attributes of Myristicin:

It is a colorless transparent liquid with a spicy smell.

The therapeutic attributes of Myristicin includes hepatoprotective, antibacterial, anti-inflammatory, antioxidant, cytotoxicity and anti-proliferation of cancerous cells, psychoactive and anti-cholinergic effects.

Hepatoprotective effect:

Myristicin found in Nutmeg offers protection to the liver. This attribute of Myristicin was focused in the study titled “Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/d-galactosamine-induced liver injury.”

This study was carried out on rats suffering from liver injury caused by Lipopolysaccharide (LPS) and d-galactosamine. It was found that Nutmeg exhibited significant protection to the liver and its main constituent, Myristicin showed remarkable hepatoprotective activity by inhibiting the release of TNF-alpha from macrophage.

Antimicrobial activity:

Myristicin shows antibacterial activity. In the study ‘Antibacterial principles from Myristica fragrans seeds’, the antibacterial effect of the constituents of the essential oil of nutmeg, namely myristicin, trimyristicin and Myristic acid were evaluated. It was determined that trimyristicin, Myristic acid and Myristicin exhibited remarkable antibacterial activity against selected gram positive and gram negative bacteria.

In the research article ‘Chemistry, antioxidant and antimicrobial potential of nutmeg (Myristica fragrans Houtt)’, it was mentioned that Myristicin is one of the important constituents of nutmeg that is responsible for the antioxidant and antibacterial activities of nutmeg.

Anti-inflammatory effect:

Myristicin is characterized by its anti-inflammatory properties. This attribute of Myristicin was discussed in detail in the study “Anti-Inflammatory Effect of Myristicin on RAW 264.7 Macrophages Stimulated with Polyinosinic-Polycytidylic Acid.”

This study revealed the anti-inflammatory effect of Myristicin which is accomplished by the inhibition of Nitric oxide, cytokines, chemokines and growth factors in dsRNA – stimulated macrophages through the calcium pathway.

Antioxidant:

A study titled “Evaluation of antioxidant activity of parsley (Petroselinum crispum) essential oil and identification of its antioxidant constituents” was carried out to evaluate the antioxidant potential of the essential oil of parsley and its constituents. It was brought into light that the essential oil of parsley showed antioxidant effect and its main constituent Myristicin presented a reasonable antioxidant effect.

Cytotoxic:

Myristicin exhibit cytotoxicity and apoptosis in human neuroblastoma cell line. Neuroblastoma is a type of cancer occurring outside the cranium of the brain. In the research article “Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells”, the cytotoxic and apoptotic activities of Myristicin on Neuroblastoma cells in humans were evaluated. It was unveiled that Myristicin was cytotoxic to Neuroblastoma SK-N-SH cells by stimulating the apoptotic mechanism in the cells.

Rhabdomyosarrcoma (RD) is a type of soft tissue cancer in childhood and in teenage years. Myristicin from nutmeg (Myristica fragrans) is cytotoxic to Rhabdomyosarrcoma cell line which is focused in the study ‘Cytogenetic study of the pure myristicin from nutmeg (Myristica fragrans) on habdomyosarrcoma cell line (in vitro).”

Further, in another study labelled ‘Antimicrobial and anti-proliferative activity of Athamanta sicula L. (Apiaceae)”, it was demonstrated that Myristicin present in the essential oil of the herb Athamanta sicula L. displayed anti-proliferative activity against human cancer cells in blood, lungs and breast namely blood cancer cells K-562, lung cancer cells NCI-H460 and breast cancer cells MCF-7.

Psychoactive:

Myristicin is considered to be one of the psychoactive component of nutmeg that alters the functioning of the brain bringing changes in attitude, insight and consciousness. This is evident from the study “Toxicity of Nutmeg (Myristicin): A Review”.

In another article “Myristica fragrans: An exploration of the Narcotic Spice”,it is stated that the psychoactive effect of myristicin is because of its metabolism into 3-methoxy 4, 5-methylenedioxyamphetamine (MMDA), which is a psychoactive compound.

Anti-cholinergic effect:

Myristicin in nutmeg was found to possess anticholinergic effect by constraining the psychological action of neurotransmitter acetylcholine in the central and in the peripheral nervous system. This attribute of Myristicin was stated in the study “Anti-Inflammatory Effect of Myristicin on RAW 264.7 Macrophages Stimulated with Polyinosinic-Polycytidylic Acid.

Reference Links:

  1. Myristicin by Wikipedia
  2. Hepatoprotective effect of myristicin from nutmeg (Myristica fragrans) on lipopolysaccharide/d-galactosamine-induced liver injury.
  3. Anti-Inflammatory Effect of Myristicin on RAW 264.7 Macrophages Stimulated with Polyinosinic-Polycytidylic Acid.
  4. Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells
  5. Cytogenetic study of the pure myristicin from nutmeg (myristica fragrans) on habdomyosarrcoma cell line (in vitro).
  6. Toxicity of Nutmeg (Myristicin): A Review

Ayurvedic Essential Oils For Eczema

Atopic dermatitis, commonly known as Eczema is the most predominant skin problems in the world. The term ‘Eczema’ is extracted from the Greek word ‘ekzein’, which means ‘to boil out’.  Eczema is a chronic skin disorder that makes the skin dry, itchy, cracked, scaly and reddened.

It is an auto-immune disease that affects people of both the gender and many of the General Practitioners say that the number of persons diagnosed for eczema is gradually increasing every year especially in North America, Western Europe, Australia and Southeast Asia. Ayurveda, the ancient healing system considers eczema as a symbol of imbalance in the human body for which it suggests the use of enriching Ayurvedic essential oils along with herbs, yoga, meditation and following an Ayurvedic routine.

Causes of Eczema: Thousands of reasons can be attributed to this auto-immune disease but eczema is said to worsen due to mental stress. Research studies also say that Eczema is common in children and numerous children who are affected by Atopic eczema also have the chances of developing asthma.

The exact reason for eczema is still not known yet the major causes of eczema are hereditary reasons, environmental factors, food and other dietary concerns, agents that cause dermatitis or eczema also known as allergens, the effect of chemical substances present in skin care products, detergents and toiletries, pet fur and much more. A reliable research done by a group of allergy experts reveal that eczema is on the rise especially in children between 6 and 7 years old in developing countries.

Symptoms of eczema: Eczema is a long-term disease that requires intense treatment. When left unnoticed, eczema gets aggravated and may lead to other serious conditions. The most prevalent symptoms of Atopic dermatitis are:

  • Dry, broken and cracked skin on the body mainly legs, arms, neck, back of the ears, hands, kneels, face, wrist, upper chest and eyelids.
  • Itchy, reddened, swollen and inflamed skin on the affected areas. This gets worsened in the night time and prolonged itching might end up in thickened and raw-looking skin.
  • Reddish or pale brown color patches appear on the skin and may develop small bumps and blisters.
  • In the extreme cases skin becomes hot, scaly, extremely dry, and sensitive. It starts oozing liquid and will attract other infections due to bacteria and other harmful foreign bodies.

Ayurveda and eczema: Eczema is termed as Vicharchika in Ayurveda. It is said that the imbalance of all the three doshas namely vata, pitta and kapha cause eczema. This skin disorder due to vata imbalance causes extreme dryness and induces severe pain and itching on the affected part. Eczema due to pitta vitiation causes burning sensation and induces oozing from the bumps whereas Kapha predominant eczema makes the skin thick along with oozing and swelling. Ayurveda is a holistic healing science that considers every individual unique with a unique constitution. Though eczema is a universal disease, Ayurvedic treatments for this disorder is specific to an individual’s physical, mental, social, environmental and spiritual set up.

Ayurvedic remedies for Eczema: Ayurvedic experts state that ‘Vicharchika’ occurs mainly due to the human body’s incapability to generate enough moisture in the skin and the abridged functioning of the immune system and the imbalance of the doshas. Ayurvedic treatments recommend keeping yourself away from those food items that are sour or salty as these can intensify your eczema. Adding turmeric, coconut, avocado, yogurt, ghee, butter to your diet has the potential to improve your skin by reducing inflammation and increasing the moisture in the skin. Ayurvedic herbs like licorice and valerian root soothes the nerves and promotes the physical balance of your body.

Turmeric is an excellent antiseptic and a renowned Nutritionist and Chinese Herbalist Daniel C. Luthi in his extensive research on Atopic Dermatitis says that the yellow pigment known as Curcumin present in Turmeric has anti-inflammatory properties and is an excellent remedy to inhibit the release and production of leukotrienes and other mediators that are inflammatory and helps in removing the toxins from the body that cause eczema and other skin disorders.

Ayurvedic oils for Eczema: Essential oils are the purest form of oils and are perfect in healing numerous skin disorders including eczema. The best recommended Ayurvedic essential oils for eczema are Lavender essential oil, Patchouli essential oil, Rosemary oil, Tea tree oil, Cypress oil, Thyme oil, Cedarwood oil, Chamomile oil and Palmarosa oil.

Physicians from the Pacific Institute of Aromatherapy in California suggest the use of a natural blend of essential oils for eczema. This blend contains 1 ml of Lavender oil and Palmarosa oil along with 10 ml of calophyllum diluted in Rose Hip Seed oil (6 teaspoons). Topical application of this blend on the affected areas will stimulate repair of cells and gradually reduce itching.

Adding few drops of Evening primrose oil to your bath tub or when used as medicated oil increases the level of omega fatty acids lacking in people affected by eczema. This oil contains gamma-linolenic acid known as GLA, which is frequently used to treat people with such skin conditions as it checks skin inflammation and allergy while evading the conversion process.

In the popular book named ‘Aromatherapy Workbook’, Shirley Price suggests the use of Frankincense essential oil, Myrrh essential oil, Hyssop essential oil for weeping eczema and Juniper essential oil and Geranium essential oil for normal eczema. Carrier oils like Borage oil, Almond oil, Calendula oil are also recommended for treating eczema.

Along with these Ayurvedic treatments, practicing simple Yoga and meditation can calm your senses, soothes your nerves and brings in tranquility to your mind thus lessening the severity of eczema.

Thought for the day:

Glamour is about feeling good in your own skin.   -Zoe Saldana

Suggested reading:

  1. Absolute Beauty: Radiant Skin and Inner Harmony Through the Ancient Secrets of Ayurveda By Pratima Raichur, Mariam Cohn
  2. Aromatherapy for Eczema By Miriam Kinai
  3. New Choices in Natural Healing: Over 1,800 of the Best Self-Help Remedies from the World of Alternative Medicine By Doug Dollemore

Reference links:

  1. Eczema: Treatment, causes, symptoms, types and diagnosis by MedicineNet.Com
  2. Childhood Eczema Still On The Increase In Developing Countries by Medical News Today
  3. Eczema or Atopic Dermatitis by Nutritional and Herbal Solutions

Best Christmas Gift Idea 2012: Adoring Ayurvedic Essential Oils

Are you thinking ‘What is wrong with me?’ wondering what’s the need for Christmas gift idea now, while there are still 4 full months for December 25th to knock your door? Come on! This is scorching summer season and to think about something that will enchant your mind, chill your senses and hearten your spirits will certainly be a brilliant idea and nothing else other than Christmas Eve has the glory to splash such joy on you. Sounds great now….. Right!! This is the right time to start your Christmas count down. Every year Christmas is exceptional in its special way. This year, you make it out of the ordinary by gifting your loved ones with warm and healing Ayurvedic essential oils rather than your usual gifts.

Your 2011 Christmas might not have been the same as your 2008 Christmas. You might have missed your loved ones or there might have been a new member to your family last year (baby!), much more adventure and a variety of gifts and that is what Christmas is all about. Make your 2012 Christmas outshine all the other festive seasons that you’ve passed in your lifetime with a wonderful pack of sensational essential oils that can take your entire family out of this world. Yes! There are certain mind-blowing Ayurvedic essential oils that suit everyone and can be used all through the year till the next Christmas comes by your way. Such enlivening essential oils are:

  1. Lavender essential oil: According to me ‘Lavender is the queen of all essential oils’ and is my all-time favorite. How can anyone keep themselves away from this magnificent oil with a mystique fragrance in it? Fill your love in a bottle full of Lavender essential oil that can uplift the spirits and refresh the mind. Wow! The wonderful color, the exuberant aroma, immense health benefits and numerous therapeutic properties like nervine, sedative, antidepressant, anti-inflammatory, expectorant, antiseptic, analgesic, anti-rheumatic, anti-convulsant and many more make Lavender very special at all the good times and sick times too!
  2. Ylang Ylang essential oil: Nothing can be so very romantic, tender, quixotic, passionate and magical like the transfixing fragrance of Ylang Ylang essential oil. This oil has emmenagogue, sedative, antiseptic, aphrodisiac, hypotensive and antidepressant properties that alleviates pain, supports mood fluctuations, controls high blood pressure, aids in frigidity problems, brings down rapid heartbeat and treats your senses.
  3. Rose essential oil: Shakespeare rightly said that ‘Rose is a rose is a rose is a rose’. Very popularly known as the symbol of love all around the universe, Rose essential oil can give you the joy of being together in a garden full of fresh, fragrant roses. Rose oil has been proven effective in treating various health conditions with its aphrodisiac, antiseptic, antiviral, antidepressant, antiphlogistic, antispasmodic, emmenagogue, uterine, bactericidal and nervine properties.
  4. Grapefruit essential oil: Grapefruit oil with its light and fresh aroma is trusted to have great effects in shedding the extra pounds of the body. Any weight loss program with essential oils cannot get fulfilled without Grapefruit essential oil. It is also an excellent skin toning agent and natural skin purifier.

Apart from these essential oils, you can also include Peppermint essential oil, Sandalwood essential oil, Sweet orange essential oil or Jasmine essential oil as per the preference of your near ones.

Love is known only when it is shown. Express your unconditional love this Christmas season with the never-ending bliss of these Ayurvedic essential oils gift pack. There’s nothing to get surprised if the love of your life asks for one the next Christmas also. Wait and watch!!!

Merry Christmas and let it be a Mesmerizing Christmas as well.

Reference links:

  1. Christmas by History.com
  2. Health benefits of Rose essential oil by Organic facts
  3. Ylang Ylang – The Great Benefits by Ylang Ylang Essential Oil