Terpinen-4-ol

Posted on December 29, 2025 by AyurvedicOils

Terpinen-4-ol is a terpene that is seen in Juniperus communis and has the molecular weight of 154.249. It is one of the major constituent of Tea tree oil that is said to be extremely active in its biological activities. It is also seen in the essential oil of Nutmeg.

Norwegian farmers use the wood from Juniperus communis to build fence as they don’t rot, and this feature is said to be attributed by the presence of Terpinen-4-ol in the bark of the tree.

In areas of medicine, Terpinen-4-ol is said to exhibit the features of an antifungal and antibacterial agent. This chemical compound is commonly seen in melaleuca oil or Tea tree oil and is highly responsible for its efficacious anti-bacterial and antifungal and anti-microbial properties.

Uses of Terpinen-4-ol:

Tea tree oil that contains Terpinen-4-ol in abundance serves as an active therapeutic agent in the treatment of several microbicidal disorders.

One study that involved the use of Tea tree oil suggested that in-vitro studies of the oil proved effective in the treatment of methicillin-resistant Staphylococcus aureus, and when used as a topical agent, it helped to get rid of nasal or extra-nasal colonization of the microorganism.

The study was carried out in 2005, but concrete evidence for it use in the industry is still awaited. An article by the American Cancer Society in the year 2008 talks on Tea tree oil, being used as an antiseptic.

Terpinen-4-ol is a potent anti-inflammatory agent and it has been concluded by a 2000 study that “Terpinen-4-ol can suppress pro-inflammatory mediator production by activated human monocytes.”

On the skin, tea tree oil can be used in the treatment of acne, dandruff, herpes, lice, and other parasitic and skin infections.

An interesting study carried out in 2012 by the National Institutes of Health stated that 5% tea tree oil gel is as effective as 5% benzoyl peroxide and can be used in the treatment of acne vulgaris.

Besides this, a recommended dosage of Tea tree oil twice a day for 6 months can cure a fungal infection, as tested on individuals with a fungal toenail infection, and athlete’s foot.

Anti-parasitic activities of Terpinen-4-ol:

A study was conducted to understand the anti-parasitic activity of Terpinen-4-ol on Demodexmites. The study concluded that Terpinen-4-ol was the most active and prominent ingredient in tea tree oil followed by Sabinene and 1, 8-Cineole. The end result stated that Terpinen-4-ol had an enhanced anti-parasitic effect in killing Demodexmites.

Antimicrobial activities of Terpinen-4-ol:

A study conducted to understand the medicinal and anti-microbial activities of Terpinen-4-ol suggests that the oil of the tea tree performs extremely well as an anti-microbial and anti-inflammatory agent. The effects of the same against fungi, viruses, and bacteria are still to be studied. A few more studies to prove the same would make the chemical compound the most favorable in the therapeutic industry.

Anti-bacterial properties of Terpinen-4-ol:

Since the 1990’s several studies and experiments were carried out to understand the effects of TTO essential oil against bacteria. Though the studies proved the positive effect of the oil in eliminating the organisms, many discrepancies were suggested regarding the methods used during the process.

So, repeated tests were performed to understand TTO and its effects on a broad range of bacterial species. The results were positive in elimination of bacteria even at minimal concentrations of 1.0% and less. The bacteria in concern were Enterococcus faecalis, staphylococci and micrococci, and Pseudomonas aeruginosa.

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β-Caryophyllene

Posted on December 29, 2025 by AyurvedicOils

Caryophyllene or (−)-β-caryophyllene, is a widespread plant natural product. It is a naturally occurring bicyclic sesquiterpene that is seen as a major composition of many essential oils. This compound is found especially in the oil extracted from the stems and flowers of cloves, the essential oil of rosemary, hemp, cannabis and hops.

It is a FDA approved food additive, and is the first dietary cannabinoid; β -caryophyllene contributes to the unique fragrance linked with plant oils. It’s also highly present in African black pepper. A study in 2008 first identified caryophyllene as a cannabinoid. This study also brought to light the medicinal benefits of the compound.

Biological activities of β-Caryophyllene:

Cannabinoids are a terpenophenolic compound making its sub-set of terpenes. Since cannabinoids and terpenes are related, terpenes trigger the body’s endo-cannabinoid receptors.

Anti-inflammatory – Decreases inflammation and swelling gradually.

Antibacterial – Curtails the growth of bacteria.

Neuro-protective – Restrains harm to the brain and the nervous system.

Anti-proliferative – Hinders the growth of cancerous cells.

Antidepressant – Mitigates various indicators of depression.

Antioxidant – Thwarts oxidative damage to the molecules in the body.

Analgesic – Alleviates pain.

Anxiolytic – Aids alleviate anxiety.

Relative studies on β-Caryophyllene:

As an analgesic:

A study in 2014 was conducted to identify the activity of β-Caryophyllene as an analgesic. It was found that the widespread plant volatile beta-caryophyllene (BCP) was identified as a natural selective agonist of the peripherally expressed cannabinoid receptor 2 (CB2), and is found in high concentrations in many spices and food plants.

This study focused on the orally administered BCP which reduced inflammatory (late phase) pain responses in the formalin test in a CB2 receptor-dependent manner, while it had no effect on acute (early phase) responses.

In conclusion of the study, oral BCP was more effective than the subcutaneously injected synthetic CB2 agonist JWH-133; meaning that the natural plant product BCP may be highly effective in the treatment of long lasting, debilitating pain states. The results have important implications for the role of dietary factors in the progression and inflection of chronic pain conditions.

As an anti-carcinogenic:

β-Caryophyllene also seems to have a play in the role as an anti-carcinogenic constituent in essential oils. A study that focused on beta-caryophyllene that analyzed the anticancer properties of alpha-humulene, Isocaryophyllene and paclitaxel was carried out in the year 2007.

The study’s focus was on the potentiating effect of beta-caryophyllene on the anticancer activity of alpha-humulene, Isocaryophyllene and paclitaxel against MCF-7, DLD-1 and L-929 human tumor cell lines was evaluated. During the study, the intracellular buildup of paclitaxel-oregon green was determined in combination with concentrations of beta-caryophyllene ranging from 2.5 to 40 microg mL(-1).

This effect was due to beta-Caryophyllene, which significantly increased the intracellular build up to 64%. Another aspect understood during the process is that, beta-caryophyllene induced intracellular buildup of calcein but not verapamil, which is an inhibitor of P-glycoprotein.

These two constituents are multidrug resistance related protein transporters, indicating that beta-caryophyllene encourages drug accumulation by a different mechanism of action. These results indicate beta-caryophyllene allows the passage of paclitaxel through the membrane and thus potentiates its anticancer activity.

As an anti-depressant:

A study was carried out on mice to check the activity of β-Caryophyllene as a remedy to depression. It was performed to understand how β-Caryophyllene, a CB2 receptor agonist produces multiple changes in behavioral patterns in accordance to depression and anxiety seen in mice.

The aim of the research experiment carried out was to determine capabilities and actions of the CB2 receptor potent-selective agonist β-caryophyllene (BCP) in animals subjected to models of anxiolytic- and antidepressant-like effects.

These preclinical results suggest that CB2 receptors may provide alternative therapeutic targets for the treatment of anxiety and depression. Recent evidence suggests that the cannabinoid receptor subtype 2 (CB2) is in co-ordinance with anxiety and depression disorders, and the study also proved the same.

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Valerian Root Essential Oil

Posted on December 27, 2025 by AyurvedicOils

‘ALL HEAL’ is how the medicinal world calls Valerian herb and more than 250 species of this plant variety. This name was derived from the Latin word ‘Valere’ meaning ‘to feel good‘ or ‘to be well’.

Yes! You might have now known why this therapeutic herb is celebrated all through these years in treating a wide range of illnesses since the 2^nd century A.D. In this context we are going to travel around the enormous health benefits of the species Valeriana Wallichii also known as Indian Valerian and is indigenous to India and is cultivated all around the world.

The most popular one among this family Valerianaceae is Valeriana Officinalis, which is native to Europe and North America but Valeriana Wallichii is used as an effective alternative to V. Officinalis with more or less the same healing values.

This herb is commonly known as Tagara in the Ayurvedic world of medicines. Ayurvedic texts suggest the use of Valerian root and the essential oil extracted from this root to treat an extensive range of illnesses including insomnia, skin problems and certain other nervous disorders. Valerian is listed as ‘Generally Recognized As Safe” by the United States Food and Drug Administration and has been approved as an effectual mild sedative by German’s Commission E.

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Historical uses of Valerian root:

Aelius Galenus, the popular Roman physician, philosopher and surgeon prescribed Valerian root for treating insomnia. Valerian tea was prescribed to treat a sick woman by Pilgram Marpeck, the Anabaptist reformer in the sixteenth century.

Dioscorides, the renowned Greek physician recommended this herb for the treatment of digestive disorders, urinary tract infections, heart palpitations, epilepsy and few other skin problems. Hippocrates, the father of western medicine also suggested Valerian root as an effective anti-depressant and as a remedy for treating insomnia.

During the medieval times in Sweden, this herb was said to be placed in the wedding clothes of the bridegroom to keep away from the envy of the elves. Such a historical mark of this herb spread its use extensively as an efficacious sedative for nervous disorders, menstrual cramps, anxiety, behavioral problems in childhood, high blood pressure, irritable bowel syndrome, learning difficulties and few other health conditions. Valerian was also used in baths to alleviate pain and promote sleep for fibromyalgia patients.

Ayurvedic health benefits of Valerian root essential oil:

Valerian Wallichii is the popular species used in the Indian Ayurvedic system of healing mankind and is known as the major species of Valeriana genus. Valeriana Wallichii is used as a significant substitute for the European species Valeriana Officinalis and has been an important part of the traditional healing system for treating skin disorders, obesity, snake poisoning, sleep disorders and nervous problems.

Charaka, the Ayurvedic philosopher has named Tagara as Sitaprasamana meaning to relieve cold feeling of the skin. This herb is also known as Sirsa dosaghna, meaning treats the illnesses of the head; Chaksusya meaning effective for the eyes; Bhutapasmara nasan meaning a promising remedy for hysteria, epilepsy and certain other evil powers; Visaghna meaning a natural anti- toxin.

According to Ayurveda, human body is made up of three predominant doshas or individual body types namely vata, pitta and kapha where vata governs metabolism and is in charge of destructions and eliminations of the body, pitta controls reasoning capacity, digestion and body temperature and kapha is responsible for the shape and structure of your body and is accountable for the power to repair the imbalances of the body. According to Ayurveda, valeriana wallichii is an effective herb in treating vata, pitta and kapha imbalances.

Valerian root essential oil is known for its deep, rich, musky and woody aroma. The essential oil of Valerian root is said to have sedative, stimulant, anti-epileptic, stomachic, antispasmodic, analgesic, carminative, analeptic and nervine properties.

The major constituents of Valerian root essential oil are limonene, borneol, pienene, sesquiterpenes, nerolidol, p-cymene, valerone, malliol, valerenic acid and 1, 8-cineole.

The chief health benefits of Valerian root essential oil are:

1. Sleeplessness and Valerian root essential oil:

The sedative property of this oil makes it a promising remedy for treating insomnia. Valerian is a well-known alternative to prescription drugs for sleeping disorders mainly because of its safe and gentle effects on the human body. Numerous studies have proved that Valerian aids people to fall asleep quicker and is also found that they have a quality sleep without any disturbances mentally.

Researchers also ensure that not like many over-the-counter sleeping pills, valerian have lesser side effects. Valerian root essential oil can be used by burning it in an aroma lamp before going to bed or used as soothing massage oil with tranquilizing carrier oils like coconut oil or by adding few drops to your bathing water in the evening.

2. Valerian oil for depression and other psycho-spiritual problems:

Renowned scientists trust that Valerian augments the amount of GABA in the brain where GABA is a chemical by name gamma aminobutyric acid. This chemical aids in promoting a calming effect on anxiety and control the nerve cells. The distinct aroma of this oil is trusted to combat seizures, anxiety, neuralgia, emotional stress, mental strain, depression, restlessness, tension and trauma.

Recent studies have proved the effectiveness of Valerian Wallichii essential oil as an effective anti-depressant and this ability to dispirit the central nervous system aids you in attaining deep hypnotic states. Tagara assists in discharging toxins from the nerves, joints, blood, colon and tissues and acts directly on the nerve channels.

3. Attention-enhancing and neurologic benefits of Valerian root:

It is a well-known fact that numerous herbalists and physicians use preparations containing Valerian essential oil in the treatment of many psychosomatic problems, peripheral, central and autonomic nervous system conditions. The attention-enhancing property of this herb has made some German physicians to use Valerian root to treat ADHD, attention deficit hyperactivity disorder in children.

4. Valerian essential oil in the treatment of pain:

According to the PMDD information blog that talks about preventing and treating severe premenstrual syndrome, valerian root is an effective natural remedy for treating PMDD problems and dysmennorhea. It is also said that the anxiety and sleeping difficulties due to premenstrual concerns can be easily treated by using this herb.

Valerian root essential oil also aids in treating migraine pains, gout pains, rheumatism and headaches due to cold. With its antispasmodic properties, this oil is also used widely in the healing of muscular spasms. Charaka Samhita says that the best way to keep away from pain and get a peaceful sleep is to take a warm, relaxing bath before bed. Adding 2 to 3 drops of Valerian oil to your bath tub can help you fight against most of your painful conditions effectively.

5. Skin disorders and Valerian root oil:

Few drops of Valerian essential oil added to your skin cream can help in treating dry scaly skin. The antibacterial properties of this oil is helpful in the remedy of burns, cuts, wounds, open sores, eczema, bruises, psoriasis, itchiness, boils, acne, scars, insect bites, stings etc. You can apply this oil externally on the affected area after blending it with your favorite carrier oils or to your skin care cream. The soothing effect of this oil will calm and cool your skin instantly.

6. Other health benefits of Valerian root essential oil:

Valerian root essential oil is a valuable remedy for treating vata disorders like facial palsy, flatulence, and paralysis. This oil is also effective in lessening kapha imbalances and is used as a natural remedy for treating asthma, whooping cough and certain other respiratory infections. The carminative and bitter properties of this oil assist in stimulating the appetite and treat indigestion and few other digestive problems like constipation, diarrhea and digestive ulcers.

Except for its pungent odor, nothing else can stop you from using Valerian root essential oil to enjoy its greater natural health benefits.

Disclaimer: Do not ingest Valerian root essential oil unless suggested by your Certified Ayurvedic Practitioner.

Thought for the day:

There is new life in the soil for every man. There is healing in the trees for tired minds and for our overburdened spirits, there is strength in the hills, if only we will lift up our eyes. Remember that nature is your great restorer. – Calvin Coolidge

Suggested Reading:

Valerian: The Genus Valeriana (Medicinal and Aromatic Plants – Industrial Profiles) From CRC Press
Valerian: The Relaxing Herb (The Herbs and Health Series) By Christopher Hobbs
Kava Kava, Valerian, Nervine Herbs (Woodland Health) By Rita Elkins

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Category Archives: Ayurvedic Essential Oils

Terpinen-4-ol

β-Caryophyllene

Valerian Root Essential Oil