α-Pinene

α-Pinene is a productive chemical constituent that’s seen in various species of coniferous trees especially the Pine. It’s also seen in Rosemary as well. α-pinene is more commonly seen in European pines; it is one of the two isomers of pine and an organic compound seen in the terpene class.

A mixture of α-pinene and α-isomer is seen in Eucalyptus oil and Orange peel oil. The chemical substance is also seen in Juniper berries and tea tree oil. The concentration and quantity of the chemical compound present in the oil depends on the temperature and availability of sunlight.

α-Pinene is seen in several essential oils and exhibits anti-inflammatory and antimicrobial properties, and acts as a broad-spectrum antibiotic. It also functions as an acetyl cholinesterase inhibitor and as a bronchodilator as well.

In ancient times, drops of the resin were collected from the bark of the trees to treat ailments. The resin collected was mixed with wine, milk or water to treat respiratory illnesses especially the ones that lead to congestion of the airway. The mixture was used as an expectorant to create relief.

The mixture of the resin were also used internally and externally to treat parasitic infections. Mixed with bees wax or animal fat, alpha-pinene was used as an antimicrobial ointment or an analgesic balm.

In the 1600, the Dutch used Juniper berries to create an alcoholic tonic which is now commonly known as Gin. This was even used as a medical aid in the ancient times. The French distilled the chemical compound from the bark of Juniper trees to create a product to treat skin diseases like eczema.

The resins containing α-Pinene called melaleuca was also put to use in the Aborigine cultures of ancient Australia to treat open wounds and prevent further infection, and also to treat fungal infections of the feet as well.

Likewise several cultures around the world used α-Pinene as tinctures, in teas and in topical formulations. As of today, this chemical constituent is being used in mouthwashes, cough lozenges, cold and chest ointments.

Antibacterial cytotoxic activity of α-Pinene:

A study conducted on Rosmarinus officinalis L. Essential Oil which contains 1,8-cineole (27.23%), α-pinene (19.43%) and β-pinene (6.71%) as its major constituents; was performed to identify the cytotoxic and antibacterial activity of the oil. The results suggested that R. officinalis L. essential oil was extremely effective towards three different kinds of cancer cells and exhibited the highest antibacterial activity.

Antimicrobial properties of α-Pinene:

Several studies have been carried out to understand the antimicrobial activities of α-pinene. One of these studies was on Biological Activities of α-Pinene and β-Pinene Enantiomers. This study was to understand the effect of the chemical substances on bacterial and fungal cells.

The study proved that α-Pinene projected an incredible amount of microbicidal activity against all fungi and bacteria when treated with MICs that ranged from 117 to 4,150 µg/mL.

Anti-inflammatory effects of α-Pinene:

Studies have proved that α-pinene exhibits anti-inflammatory effects in human Chondrocytes; keeping this in mind a study was carried out to establish an understanding on α-pinene and its anti-osteoarthritic activity.

The results focused positive feedback on the effects of α-pinene as an anti-inflammatory, anti-catabolic and anti-osteoarthritic and should be studied further for its promising activity as an anti-osteoarthritic drug.

Reference links:

  1. Antibacterial Activity and Anticancer Activity of Rosmarinus officinalis L. Essential Oil Compared to That of Its Main Components by Wei Wang, Nan Li, Meng Luo, Yuangang Zu and Thomas Efferth, published in Molecular Diversity Preservation International Journal.
  2. What are the medical uses of alpha-pinene? By WiseGeek
  3. Anti-inflammatory and Chondroprotective Activity of (+)-α-Pinene: Structural and Enantiomeric Selectivity by University of Coimbra, Portugal, published in the Journal of Natural Products.

Patchouli alcohol

Patchoulol or patchouli alcohol (C15H26O) is a sesquiterpene alcohol found in Patchouli. It also goes by the name, Patchouli camphor;(–)-patchoulol; (1R, 3R, 6S, 7S, 8S)-patchoulol, patchouli alcohol.

The (−)-optical isomer is one of the organic compound that imparts the scent of patchouli; it’s a colorless to pale yellow crystalline solid. Due to its pleasant fragrance, it is used as an important material in perfumery.

The oil has proven activity as anti microbial, inhibiting platelet activating factor (PAF), antiseptic, antiviral, sedative agents, and antifungal.

The organo nitrogen compounds of the oil functions with biological activities as a vasodilator, antiviral, antidepressants, antimicrobial, anti-schistosomal, anti-inflammatory, analgesic, antitumor, and anticonvulsant. The chemotherapy drug Taxol is also synthesized from this very oil.

Therapeutic uses of Patchouli alcohol:

Some studies reported the potential of patchouli oil for medicinal application. This compound is commonly associated to biological and physiological activity for disorders of the central nervous system and its capability to cooperate with receptors of the body.

The most prominent remedial attributes of Patchouli alcohol are:

Patchouli alcohol as an antioxidant:

A study on ‘Antioxidant Activities and Volatile Constituents of Various Essential Oils’ was carried out in the year 2007. During the process, thirteen essential oils were analyzed to determine their antioxidant activity using three different assay systems.

The main compounds seen in the oil which showed extensive antioxidant traits were, limonene (composition, 74.6%) in celery seed, benzyl acetate (22.9%) in jasmine, α-pinene (33.7%) in juniper berry, myristicin (44%) in parsley seed, patchouli alcohol (28.8%) in patchouli, citronellol (34.2%) found in rose, and germacrene (19.1%)  seen in ylang−ylang.

Bacterostatic, antifungal & larvicidal activity of Patchouli alcohol:

In 2004 a study to check the larvicidal activity of the essential oil of Teucrium leucocladum Boiss was conducted. During this study, the chemical composition of the water-distilled essential oil and n-hexane–ether extract of Teucrium leucocladum Boiss were identified by GLC and GLC–MS techniques. As a result 72 compounds were identified.

The sesquiterpene alcohols, patchouli alcohol (31.24% and 29.66%) and α-cadinol (9.29% and 21.54%) were the main components in the oil.

On analyzing the resulting extracts to identify their antifungal and bacterostatic activities, it was proved that they showed broad and potent activity against Bacillus subtilis, Candida albicans and Pseudomonas aeruginosa.

Patchouli alcohol as an Anti-inflammatory:

‘Anti-inflammatory activity of patchouli alcohol in RAW264.7 and HT-29 cells’ study performed in the year 2013 states that “PA inhibits the production of inflammatory mediators.” During the study, it was analyzed and documented to check if the PA brings on a reduction in the production of inflammatory mediators through down regulation of the NF-κB and ERK pathway.”

The above mentioned results suggested that PA shows anti-inflammatory activities through suppressing ERK-mediated NF-κB pathway in mouse macrophage and human colorectal cancer cells.

Antibacterial activity of Patchouli oil:

A study on the antimicrobial tests of patchouli oil was carried out by using a technology called molecular docking and antimicrobial test done in vitro. In the study, five biological macromolecule enzymes, required by the bacteria in the process of biosynthesis were selected as the objective molecules.

“A group of antibiotics benzyl penicillin, sulfadiazine, trimethoprim, rifampicin and ciprofloxacin, commonly known as antibacterial drugs, were selected as reference compounds.” The 3 three-dimensional of the 5 reference compounds used and the 26 compounds from patchouli oil were analyzed using surflex-dock software.

Here patchouli oil and its two major compounds, pogostone, and (-)-patchouli alcohol which exceeded 60% in patchouli oil samples, were selected antibacterial agents. The conclusion: “Molecular docking technology and antimicrobial test in vitro proved that patchouli oil had strong antimicrobial effects.” Of which, pogostone and (-)-patchouli alcohol displayed effective antimicrobial activity.

Reference Links:

  1. Patchoulol by Wikipedia
  2. Anti-inflammatory activity of patchouli alcohol in RAW264.7 and HT-29 cells, by Department of Nutrition and Food Science, University of Maryland, published in Food Chemical Toxicology
  3. Evaluation of the Antibacterial Activity of Patchouli Oil, published in the Iranian Journal of Pharmaceutical Research and PubMed

Oregano Essential Oil

oregano-bannerAcclaimed as ‘The Mediterranean Miracle’, ‘Mountain Joy’ and as the ‘Wonder Herb in Ayurveda’, Oregano has been aiding people all over the world and especially in the Mediterranean regions to maintain healthy living for numerous centuries.

The most popular Ayurvedic book, ‘Yoga of Herbs: An Ayurvedic Guide to Herbal Medicine’ by Dr. David Frawley and Dr. Vasant Lad says “Oil of Oregano is one of the most potent antiseptics known to man.

Botanically known as Origanum Vulgare, Oregano is yet another prestigious limb of the mint family, Lamiaceae and has its origin in the Mediterranean region and southwestern Eurasia. Ayurveda, the mother of all healing sciences used Oregano (known as Sathra) and its essential oil as a heating carminative to treat digestive disorders and was also used for treating toothache, skin problems, pain and inflammation.

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Historical uses of Oregano essential oil and the herb:

Known as the staple herb of the Italian-American cuisine, Oregano is one among the best culinary herbs in the world used in a variety of Mediterranean cuisines, Mexican food, Italian dishes and is also used in making fried, roasted or grilled vegetables, meat, fish and much more food varieties. It is also a part of many Lebanese, Turkish, Palestinian, Spanish, Greek, Portuguese, Syrian, Latin American and Egyptian cuisines.

Oregano essential oil is extracted from the leaves of this plant. This oil has been in use since the primordial times in various medicinal practices. The Traditional Chinese Medicine used Oregano for treating vomiting, fever and diarrhea. The fresh leaves were used in tea for strengthening the immune system and for dealing with infections.

Biblical texts denote Oregano as a cleansing tonic. The ancient Arabic medicine used this herb for food preservation and for treating gastrointestinal disorders. The natural medicinal system of Philippines used Oregano and its essential oil for treating cough and ear aches in children. It was also used in curing pain and given for women after childbirth for its emmenagogue properties.

Hippocrates, the ancient Greek physician and the father of western medicine used Oregano as an effective antiseptic and for treating respiratory and digestive ailments. History denotes that it was the Greeks who discovered the disinfectant and antimicrobial properties of this oil and they used it for treating skin infections, sore throat, wounds, viral infections and for protecting the body from the effect of harmful organisms.

Chemical constituents and therapeutic properties of Oregano oil:

Oregano essential oil is enriched with chemical constituents like carvacrol, cymene, thymol, borneol, terpinene, pinene, linalyl acetate, bisabolene, linalool, caryophyllene and geranyl acetate. The remedial properties of this oil are antimicrobial, antiseptic, anti-viral, anti-bacterial, anti-parasitic, antioxidant, emmenagogue, anti-allergenic, digestive, anti-inflammatory and immune stimulant.

Ayurvedic health benefits of Oregano essential oil:

Ayurveda means ‘science of life’, the science that preaches the simple methodologies to prevent illness, stay healthy and for healthy aging that makes you independent in your 60s or 70s without relying upon anyone to assist your health conditions.

The philosophy of Ayurveda relates the life of an individual with the life of the Universe. Based upon this innate wisdom, Ayurveda further explains that the Universe is made up of five elements namely fire, water, earth, air and ether and it also states that an individual is also made up of the five elements of nature, which is also known as the building blocks of life.

Among these five elements water governs the movement of fluids in the body like blood, saliva, mucus and plasma. Fire determines the digestive power, intellectual skills and body temperature. Air controls the functioning of the heart, stomach, lungs, joints and intestines.

Ether is present in all parts of the human body where the presence of cavity and emptiness are witnessed like heart, nostrils, blood vessels, bladder etc. Earth represents vigor, braveness, constancy and steadiness.

The individual constitution comprises of three energy elements known as doshas (vata, pitta and kapha). Vata represents air and ether, pitta stands for fire and water and kapha stands for water and earth. Imbalance of doshas leads to illnesses.

Ayurveda recommends the use of herbs, essential oils, healthy lifestyle, meditation and yoga to bring the body and mind back to balance. Oregano oil is known to enhance pitta deficiency and reduce kapha and vata excess.

The major Ayurvedic health benefits of Oregano essential oil are:

Oregano-broucher1. Protects the body from infections and allergies:

Oregano oil has been proved effective for treating numerous infections and allergic conditions with its antibiotic, antimicrobial, anti-viral, anti-bacterial and anti-parasitic properties.

The Georgetown University research on Oregano oil’s effectiveness against drug-resistant bacteria, proves that the presence of carvacrol component in Oregano oil lessen the infections as effectively as the traditional antibiotics.

A study conducted by the Mexican researchers on the effectiveness of Oregano to treat giardia, which is a water-borne bacterium that lives inside the intestines. Another study proves that Oregano oil is effective in killing giardia bacterium than the generally prescribed drug tinidazol. Oregano is a powerful anti-bacterial oil that wards off numerous pathogenic bacteria like E.coli, Staphylococcus aureus and Strep and protects one from typhoid, sores, cholera, infections in the colon, urinary tract and certain other skin infections.

Parasites like tape worms, round worms, mosquitoes, fleas, lice and bed bugs cause innumerable communicable diseases that affect the human body severely. Oregano essential oil has anti-parasitic properties that aids in killing parasites.

Viral infections like cold, pox, mumps and measles weaken your immune power and paves way for other harmful organisms to affect your health. Oregano essential oil is a powerful immune stimulant that strengthens your immune system, fight against viruses and makes your system resistant to other foreign bodies.

Fungal infections like athlete’s foot and ringworm can be treated aromatically with the antifungal properties of this oil. Being an anti-allergenic oil, Oregano acts as a sedative and pacifies the hyper-sensitive reaction responsible for allergies.

A 2001 research on ‘Antimicrobial activity of essential oils from plants against selected pathogenic and saprophytic microorganisms’ proved that among the 11 essential oils tested for effectiveness against microbes, Oregano essential oil showed the highest inhibitory rate against pathogenic and spoilage microorganisms. The carvacrol and thymol compounds in this oil are very effective in killing a microbe known as Candida, which is the reason behind eczema and psoriasis.

To guard yourself against such infections and allergies, you can either topically apply 2 drops of Oregano oil blended with olive oil on the affected area or add 2 drops of oil in your bath or skin care cream or lotions.

2. Promotes digestive health:

Oregano essential oil is a heating carminative oil that aids in increasing the pitta flow and promotes quicker digestion. Massaging your tummy with 2 drops of Oregano oil blended with sesame oil can assist in treating slow digestion due to excess of mucous deposits in the stomach or fullness.

You can also add 2 to 3 drops of Oregano oil in warm compresses to help with stomach upsets, relieving gas, enabling the movement of food and for regularizing the entire process of digestion.

3. Assists respiratory problems:

As Oregano essential oil has warming effect, it can assist the body when it is cold and treat problems like cold, sinusitis, headache, mucous congestion, whooping cough, pneumonia and other respiratory infections. Oregano essential oil is said to be one of the best essential oils for opening blocked sinus passages and treat congestion as a natural decongestant.

Light Miller in her book ‘Ayurveda and Aromatherapy’ says that Oregano essential oil is a warming diaphoretic oil that eliminates surface toxins, provoke perspiration, improve blood circulation and relieve headaches due to congestion or cold.

Add 2 drops of Oregano oil to steaming water and inhaling this medicated steam will aid in alleviating congestion, open blocked nasal passages and relieve pain due to cold and infection. You can also blend 2 drops of Oregano oil with coconut oil and gently massage the soles of your feet or apply on your chest and back or add it to warm bathing water for immediate relief from cold, sore throat and sinus problems.

4. Helps relieve pain and inflammation:

The anti-inflammatory, immune stimulant and warming diaphoretic properties of Oregano oil assist in eliminating toxins from the body, reduce inflammation, increase blood circulation and lessen pain and inflammation in rheumatic and arthritic patients.

Gently massaging the affected area with 2 drops of Oregano oil blended with coconut oil or adding it to your bath helps in reducing pain and inflammation in arthritis. Oregano essential oil has been proved by the Physiotherapy research to contain morphine-like properties that act as a perfect pain relief aid.

5. Fights against prostate cancer:

The University of Arizona research and the study by the Long Island University have proved that Oregano essential oil has antioxidant and anti-cancerous properties that fights against many types of human cancers.

Prostate cancer has been listed as the second important cause of cancerous death in American men. This study found that the presence of the active constituent, carvacrol in Oregano oil helps in the treatment of prostate cancer by stimulating apoptosis (programmed death of cells) in prostate cancer cells.

Other health benefits:

Oregano essential oil also helps in alleviating dysmennorhea, normalizing blocked menstruation and treating menopausal symptoms. This oil is also used for treating intestinal parasites, muscular pain, warts, vaginal candida and asthma.

Disclaimer:

Never use essential oils directly on the skin and always dilute it in suitable carrier oils as essential oils are highly concentrated solutions. Avoid using essential oils internally. Consult your Ayurvedic physician before using the right essential oils for your unique individual constitution and state of health. Avoid using essential oils if you are pregnant or a nursing mother.

Thought for the day:

In all things of nature there is something of the marvelous.    -Aristotle

Suggested Reading:

  1. Oregano – The Herb that Saved…My Life by Thomas Mayhew
  2. The Cure Is in the Cupboard: How to Use Wild Oregano for Better Health by Cass Ingram
  3. The Oregano Oil Supplement: Alternative Medicine for a Healthy Body (Health Collection) by William Wagner
  4. Herbal Antibiotics, 2nd Edition: Natural Alternatives for Treating Drug-resistant Bacteria by Stephen Harrod Buhner

Reference Links:

  1. Oregano Oil May Protect Against Drug-Resistant Bacteria by the Georgetown University Researcher published in Science Daily
  2. Oregano by Wikipedia
  3. Antimicrobial activity of essential oils from plants against selected pathogenic and saprophytic microorganisms published in PubMed
  4. Oregano Active Constituent Kills Prostate Cancer Cells by Herbcyclopedia